Predictive Value of Serum Soluble Growth Stimulation Expressed Gene 2 Protein Level for the Prognosis of Patients with Sepsis-associated Acute Kidney Injury
ZHENG Dedong
CHEN Qiuru
WEI Beilei
LUO Xu
ZOU Junfeng
Abstract：Objective To explore the predictive value of serum soluble growth stimulation expressed gene 2 protein(sST2)level for sepsis-associated acute kidney injury(SA-AKI).Methods Seventeen patients with SA-AKI admitted to the People's Hospital of Longhua,Shenzhen from February 2023 to February 2025 were selected as the study subjects(SA-AKI group),and 17 patients with simple sepsis were selected as the control group.The basic clinical data and laboratory test results of the two groups of patients within 24 hours of admission were collected,and the serum sST2 levels of the two groups of patients were compared.The correlation between serum sST2 levels and sequential organ failure assessment score(SOFA)and acute physiology and chronic health evaluation score(APACHE II)was analyzed.By drawing the receiver operating characteristic(ROC)curve,the area under the curve(AUC)of serum sST2 levels and related laboratory indicators was compared,and the predictive value of serum sST2 levels for SA-AKI was analyzed.Results The serum sST2 level of the SA-AKI group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05);The increase in serum sST2 level was positively correlated with SOFA and APACHE II scores.The R2 values of the scatter plots were 0.574 and 0.676,respectively.The ROC curve was drawn,and the AUC(95%CI)of serum sST2 level for predicting SA-AKI was 0.871(0.752-0.991),which was higher than other laboratory indicators,and the difference was statistically significant(P<0.05).Conclusion The serum sST2 level of SA-AKI patients was significantly increased,and the serum sST2 level has a certain predictive value for SA-AKI.
Keywords：SepsisAcute kidney injurySoluble growth stimulation expressed gene 2 proteinPredictive value
Publication Date：2025-12-30
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：6( 1-5,后插1 )