Correlation between Adiponectin,Interleukin-6 and Postoperative Atrial Fibrillation in Patients with Aortic Stenosis after Valve Replacement
LU Zenghui
LIU Yufeng
LU Yingmin
Abstract：Objective To explore the correlation between adiponectin(APN),interleukin-6(IL-6)and postoperative atrial fibrillation(AF)in patients with aortic stenosis after valve replacement.Methods The clinical data of 66 patients with aortic stenosis who underwent valve replacement in the department of cardiac surgery of Zhengzhou Central Hospital from March 2020 to February 2025 were retrospectively analyzed.The patients were divided into an occurrence group(45 cases)and a non-occurrence group(21 cases)based on whether they developed AF within 72 hours after surgery.The general data,preoperative serum APN and IL-6 levels of the two groups were compared,and the correlation between APN,IL-6 and postoperative AF in patients with aortic stenosis after valve replacement was analyzed.Results The left ventricular ejection fraction(LVEF)of the occurrence group was lower than that of the non-occurrence group,and the left atrial diameter(LAD)and left ventricular end-diastolic diameter(LVEDD)were longer than those of the non-occurrence group,with statistically significant differences(P<0.05).The level of serum APN of the occurrence group was lower than that of the non-occurrence group,and the level of serum IL-6 was higher than that of the non-occurrence group,with statistically significant differences(P<0.05).Logistic regression analysis showed that high levels of serum APN and high LVEF are protective factors for postoperative AF in patients(OR=0.370,0.697,P=0.035,0.049),while high levels of serum IL-6 are risk factors for postoperative atrial fibrillation in patients(OR=1.187,P=0.039).Conclusion APN and IL-6 are related to postoperative AF in patients with aortic stenosis after valve replacement.When serum APN is expressed at a low level and IL-6 is expressed at a high level,the risk of postoperative AF in patients increases significantly.
Keywords：Aortic stenosisAtrial fibrillationOpen-chest valve replacementAdiponectinInterleukin-6Correlation analysis
Publication Date：2025-10-15
Online Publishing Date：2025-12-29(First online date of this platform, not the publication date of the document)
Pages：4( 24-26,35 )