Adverse Reaction Monitoring and Pharmaceutical Service Intervention of β-Lactam Antibiotics in the Pediatrics Department of Xinyang Municipal Hospital of Traditional Chinese Medicine

LU Guiru; MA Mengcheng; LIU Jingyang

doi:10.16458/j.cnki.1007-0893.2025.18.008

Abstract：Objective To monitor the adverse reactions of β-lactam antibiotics in the pediatrics department of Xinyang Municipal Hospital of Traditional Chinese Medicine and provide guidance for pharmaceutical service intervention.Methods A retrospective analysis was conducted on the medical records of 116 children treated with β-lactam antibiotics in the pediatrics department of Xinyang Municipal Hospital of Traditional Chinese Medicine from May 2023 to May 2025.The occurrence of adverse reactions,involved drugs,affected systems-organs,and clinical manifestations were statistically analyzed.The children were divided into an occurrence group and a non-occurrence group based on whether adverse reactions occurred.Univariate and multivariate Logistic regression analyses were used to identify the independent risk factors for adverse reactions after treatment with β-lactam antibiotics in children.Results Among the 116 children treated with β-lactam antibiotics,22 cases had adverse reactions,with an incidence rate of 18.97%(22/116).Among them,a highest incidence of adverse reactions was observed with amoxicillin-clavulanate,piperacillin-tazobactam,and ceftriaxone,accounting for 22.73%,18.18%,and 13.64%,respectively.Adverse reactions mainly affected the skin and appendages system,hematological system,and digestive system,with less impact on other systems.Univariate analysis showed that the proportion of children in the occurrence group who received intravenous injection and high-dose administration were higher than those in the non-occurrence group,and the duration of medication was longer,with statistically significant differences(P<0.05).Multivariate Logistic regression analysis showed that intravenous injection,high-dose administration,and long duration of medication were independent risk factors for adverse reactions after treatment with β-lactam antibiotics in children(OR>1,P<0.05).Conclusion The incidence of adverse reactions to β-lactam antibiotics in the pediatrics department of Xinyang Municipal Hospital of Traditional Chinese Medicine is relatively high.Intravenous injection,high-dose administration,and long duration of medication are independent risk factors for adverse reactions.It is recommended to formulate pharmaceutical service intervention measures based on these factors to reduce the risk of adverse reactions to β-lactam antibiotics.