Expression of RSPO2,p53 and Ki-67 in Esophageal Squamous Intraepithelial Neoplasia and Its Clinical Significance
SHENG Furong
FAN Yibo
DENG Peng
CHENG Zhiqiang
PENG Quanzhou
Abstract：Objective To explore the expression of RSPO2,p53 and Ki-67 in esophageal squamous intraepithelial neoplasia(ESIN)and their clinical significance.Methods This study compared the immunohistochemical(IHC)expression of the new marker RSPO2 with p53 and Ki-67 in different types of esophageal squamous lesions and evaluated the correlation of their expression levels in these lesions.Results RSPO2 and Ki-67 had high sensitivity and specificity for the diagnosis of ESIN.The sensitivity of RSPO2 in differentiating high-grade intraepithelial neoplasia(HGESIN)from low-grade intraepithelial neoplasia(LGESIN)was as high as 97.92%,but the specificity was only 72.00%.Strong staining of RSPO2 had a specificity of 100.00%in differentiating HGESIN from LGESIN,but the sensitivity was as low as 29.17%.High expression of Ki-67 and p53 had a specificity of 96.00%in differentiating HGESIN from LGESIN,but the sensitivity decreased to 56.25%and 62.50%,respectively.Conclusion This study indicates that both RSPO2 and Ki-67 can be used for the differential diagnosis of ESIN.
Keywords：Esophageal squamous intraepithelial neoplasiaEndoscopic submucosal dissectionRSPO2p53Ki-67
Publication Date：2025-09-30
Online Publishing Date：2025-12-22(First online date of this platform, not the publication date of the document)
Pages：6( 30-33,41,后插3 )