Application Value of Combined Detection of Basal LH,IGF-1,AMH and ADPN in Predicting Central Precocious Puberty in Girls

WANG Liwei; CAO Fuqing; LI Can

doi:10.16458/j.cnki.1007-0893.2025.17.009

Abstract：Objective To explore the predictive value of basal luteinizing hormone(LH),insulin-like growth factor-1(IGF-1),anti-Müllerian hormone(AMH),adiponectin(ADPN),and their combined detection for central precocious puberty(CPP)in girls.Methods A total of 120 girls with precocious puberty admitted to the First Affiliated Hospital of Henan University of Chinese Medicine from January 2022 to December 2024 were selected as the research subjects and divided into a CPP group(48 cases)and a peripheral precocious puberty(PPP)group(72 cases)based on the type of precocious puberty.The levels of serum AMH,ADPN,IGF-1,and basal LH were compared between the two groups.The correlation between basal serum LH,IGF-1,AMH,ADPN levels and CPP was analyzed by Spearman correlation analysis,and the predictive efficacy of each index and their combination was evaluated by receiver operating characteristic(ROC)curve.Results The levels of basal LH,IGF-1,and AMH in the CPP group were all higher than those in the PPP group,while the level of ADPN was lower,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that basal LH,IGF-1,and AMH levels were positively correlated with CPP(r>0,P<0.05),while ADPN level was negatively correlated with CPP(r<0,P<0.05).ROC curve analysis showed that the area under the curve(AUC)for the prediction of CPP using basal LH,IGF-1,AMH and ADPN was all greater than 0.7,among which the combined detection had the highest AUC(0.942).Conclusion Elevated basal serum LH,IGF-1,and AMH levels and decreased ADPN level are associated with CPP.Combined detection of basal LH,IGF-1,AMH,and ADPN has a high predictive value for CPP in girls.