Analysis of Related Factors of Adverse Pregnancy Outcomes in Patients with Endometriosis Combined with Infertility Treated with Mifepristone

MA Huixiao; LI Mei; GUO Shuanghua

doi:10.16458/j.cnki.1007-0893.2025.17.006

Abstract：Objective To investigate the influencing factors of adverse pregnancy outcomes in patients with endometriosis(EM)and infertility treated with mifepristone.Methods A total of 65 patients with EM and infertility admitted to Yucheng County People's Hospital from March 2021 to September 2024 were selected as the research subjects.They were divided into an adverse pregnancy outcome group and a non-adverse pregnancy outcome group based on whether they experienced adverse pregnancy outcomes after mifepristone treatment.The baseline and clinical data of the two groups were compared,and the items with significant differences were entered into the Logistic regression equation for statistical analysis to explore the influencing factors of adverse pregnancy outcomes in patients with EM and infertility after mifepristone treatment.Results Among the 65 patients with EM and infertility,21 patients experienced adverse pregnancy outcomes after mifepristone treatment and were included in the adverse pregnancy outcome group;44 patients did not experience adverse pregnancy outcomes and were included in the non-adverse pregnancy outcome group.The FMS-IW-control type fertility motivation score and the frequency of uterine cavity operations in the adverse pregnancy outcome group were higher than those in the non-adverse pregnancy outcome group,while the number of retrieved oocytes was lower,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that the FMS-IW-control type fertility motivation score and the frequency of uterine cavity operations were risk factors for adverse pregnancy outcomes in patients with EM and infertility after mifepristone treatment(OR>1,P<0.05),while the number of retrieved oocytes was a protective factor(OR<1,P<0.05).Conclusion The influencing factors of adverse pregnancy outcomes in patients with EM and infertility treated with mifepristone include the FMS-IW-control type fertility motivation score,the frequency of uterine cavity operations,and the number of retrieved oocytes.Clinically,these factors can be used to screen high-risk groups for adverse pregnancy outcomes and provide reference value for the formulation of prevention and treatment plans for adverse pregnancy outcomes.