Mechanism of Action of Qingyi Tongfu Decoction in the Treatment of Hyperlipidemic Acute Pancreatitis was Explored Based on Network Pharmacology and Molecular Docking Technology
LIN Chenhui
Abstract：Objective To explore the potential active components and action targets of Qingyi Tongfu Decoction in the treatment of hyperlipidemic acute pancreatitis(HLAP)by using network pharmacology and molecular docking technology,and to investigate its possible mechanism of action.The binding ability of key active components and core targets was verified by molecular docking.Methods The active components and their action targets of Qingyi Tongfu Decoction were screened through TCMSP and BATMAN-TCM databases.The related targets of HLAP were obtained from Drugbank,GeneCards,OMIM and other databases.The intersection targets of drugs and diseases were taken as the potential action targets of Qingyi Tongfu Decoction in the treatment of HLAP.The protein-protein interaction(PPI)network of potential targets was constructed by STRING database and imported into Cytoscape software.The core targets were screened by CytoHubba plugin.Meanwhile,a"Chinese medicine-active component-intersection target"network diagram was constructed to visualize the multi-component-multi-target relationship.The intersection targets were analyzed for gene ontology(GO)functional enrichment and Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment by DAVID database,and bubble charts were drawn using R language.Finally,the key active components and core targets in the network were selected and molecular docking was performed using AutoDockTools,PyMOL and other software.Results There were 49 potential action targets of Qingyi Tongfu Decoction in the treatment of HLAP.KEGG pathway enrichment analysis showed that these targets were significantly enriched in key pathways such as the AGE-RAGE signaling pathway of diabetic complications,lipid and atherosclerosis pathways,and PI3K/AKT signaling pathways.Molecular docking results showed that the key active components and core targets all exhibited strong binding activity.Conclusion Qingyi Tongfu Decoction treats HLAP through multi-component and multi-target effects,providing an effective theoretical basis for the treatment of HLAP with Qingyi Tongfu Decoction.
Keywords：Hyperlipidemic acute pancreatitisNetwork pharmacologyMolecular docking technologyMechanism of action
Publication Date：2025-09-15
Online Publishing Date：2025-12-22(First online date of this platform, not the publication date of the document)
Pages：5( 11-14,后插3-后插5 )