Exploration of the Mechanism of Qingluo Wenfei Decoction in Treating Interstitial Lung Disease Based on Network Pharmacology and Molecular Docking
GUO Mengru
HE Dongyi
SUN Wei
JIANG Ping
SHEN Pi'an
ZHANG Yuanyuan
Abstract：Objective To explore the action targets and signaling pathway mechanisms of Qingluo Wenfei Yin in the treatment of interstitial lung disease(ILD)through network pharmacology and molecular docking methods.Methods The effective compounds and targets of Qingluo Wenfei Yin were obtained by consulting literature and databases such as TCMSP,ETCM,HERB,PubChem,and SwissTargetPrediction.The targets related to ILD were searched through databases such as GeneCards,OMIM,and DisGeNET.The targets of the disease and the compounds of Traditional Chinese Medicine were integrated through the STRING database to construct a protein interaction network and reveal the key targets of Qingluo Wenfei Yin in the treatment of ILD.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)enrichment analysis was conducted using the David database to explain the mechanism of Qingluo Wenfei Yin in the treatment of ILD.Finally,molecular docking was used to dock the key compounds and targets.Results A total of 204 effective compounds and 1023 related targets of Qingluo Wenfei Yin were obtained,and 2902 targets related to ILD were obtained.The key targets for the treatment of ILD were SRC,IL-6,TP53,and AKT1.The biological functions of Qingluo Wenfei Yin mainly included protein phosphorylation,inflammatory response,and regulation of cell proliferation.The main signaling pathways involved in the treatment of ILD were PI3K-Akt and HIF-1.Molecular docking showed that the key compound schizandrin had good molecular binding ability with AKT1,SRC,and TP53.Conclusion Qingluo Wenfei Yin may play a role in the treatment of ILD by acting on the targets SRC,IL-6,TP53,and AKT1 and regulating the signaling pathways PI3K-Akt and HIF-1.
Keywords：Interstitial lung diseaseQingluo Wenfei YinNetwork pharmacologyMolecular docking
Publication Date：2025-08-15
Online Publishing Date：2025-11-17(First online date of this platform, not the publication date of the document)
Pages：7( 1-4,13,后插1,封3 )