Correlation Study of HbA1c,Ambulatory Arterial Stiffness Index,Non-dipping Blood Pressure and Cerebral Microbleeds in Patients with Acute Ischemic Stroke
NIU Yuanyuan
WANG Xiuqing
JI Yubing
Abstract：Objective To explore the correlation between glycated hemoglobin(HbA1c),ambulatory arterial stiffness index(AASI),and non-dipping blood pressure and cerebral microbleeds in patients with acute ischemic stroke.Methods A total of 120 patients with acute ischemic stroke(without cerebral microbleeds)admitted to Kaifeng Central Hospital from January 2019 to December 2023 were selected as a control group,and 120 patients with cerebral microbleeds after acute ischemic stroke during the same period were selected as an observation group.The clinical characteristics of the two groups were compared.The AASI and non-dipping blood pressure were calculated based on 24-hour ambulatory blood pressure(ABPM)monitoring.The correlations between the level of HbA1c,AASI and non-dipping blood pressure and cerebral microbleeds were analyzed by Spearman rank correlation,and the effects of each variable on cerebral microbleeds were analyzed by multivariate Logistic regression.Results There were statistically significant differences in the previous stroke history,the level of HbA1c,AASI and non-dipping blood pressure between the two groups of patients(P<0.05).Spearman rank correlation analysis showed that cerebral microbleeds were positively correlated with the level of HbA1c,AASI and non-dipping blood pressure(r>0,P<0.05).Multivariate Logistic regression analysis showed that the level of HbA1c,AASI and non-dipping blood pressure were independent risk factors affecting the occurrence of cerebral microbleeds(P<0.05).Conclusion HbA1c,AASI and non-dipper blood pressure are important influencing factors for cerebral microbleeds in patients with acute ischemic stroke and can be used as independent factors for predicting the occurrence of cerebral microbleeds in patients.
Keywords：Acute Ischemic strokeCerebral microbleedsGlycated hemoglobinAmbulatory arterial seiffness indexNon-dipping blood pressure
Publication Date：2025-04-30
Online Publishing Date：2025-08-25(First online date of this platform, not the publication date of the document)
Pages：4( 16-19 )