Effect of Caffeine Citrate in the Treatment of Severe Neonatal Respiratory Distress Syndrome and Its Impact on Inflammation
SONG Yuan
DU Wenyan
WANG Jingjing
LIU Yulu
Abstract：Objective To explore the effect of caffeine citrate in the treatment of severe neonatal respiratory distress syndrome(NRDS)and its influence on inflammation.Methods A total of 96 children with severe NRDS who were treated in the First People's Hospital of Shangqiu from July 2021 to December 2022 were selected as the research subjects.They were divided into a control group[given conventional treatment combined with high-frequency oscillatory ventilation(HFOV)treatment]and an observation group(treated with caffeine citrate on the basis of the control group),with 48 cases in each group according to different treatment methods.The therapeutic effects,blood gas analysis indicators,serum inflammatory factor levels and the occurrence of complications of the two groups of children were compared.Results The total effective rate of treatment in the observation group was 95.83%,which was higher than 81.25%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the arterial partial pressure of oxygen(PaO2)in the observation group was higher than that in the control group,and the arterial partial pressure of carbon dioxide(PaCO2)was lower than that in the control group.The differences were statistically significant(P<0.05).After treatment,the levels of serum interleukin-6(IL-6),Clara cell secretory protein 16(CC16),and high-sensitivity C-reactive protein(hs-CRP)in the observation group were all lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of complications such as bronchopulmonary dysplasia,pulmonary infection,airway injury,and heart failure between the two groups of children(P>0.05).Conclusion Caffeine citrate treatment can enhance the therapeutic effect of children with severe nrds,effectively reduce their inflammatory response,improve their blood gas indicators,and has a relatively high safety.
Keywords：Severe neonatal respiratory distress syndromeCaffeine citrateInflammation reaction
Publication Date：2025-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 5-8 )