Clinical Observation on the Treatment of Hyperthyroidism Combined with Leukopenia with Eleven Flavor Shenqi Tablets and Methimetazole

ZHANG Yuting; QIU Jianzhao; DENG Xiaoyan

doi:10.16458/j.cnki.1007-0893.2024.23.006

Abstract：Objective To explore the clinical efficacy of Eleven Flavor Shenqi tablets combined with methimazole in the treatment of patients with hyperthyroidism and leukopenia.Methods A total of 88 patients with hyperthyroidism and leukopenia admitted to Sanming First Hospital from January 2022 to January 2023 were selected as the research subjects.The study was divided into an observation group and a control group by drawing lots,with 44 patients in each group.The control group was treated with methimazole,while the observation group was treated with a combination of Eleven Flavor Shenqi tablets and methimazole.The clinical efficacy,traditional Chinese medicine syndrome scores,white blood cell count,and related thyroid hormone levels before and after treatment were compared.Results The total effective rate of treatment in the observation group was 95.45%,which was higher than 77.27%in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of finger tremor,goiter,less sleep and more dreams,irritability,palpitation,lethargy and fatigue in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The white blood cell count of the observation group patients was higher than that of the control group after 1 week,1 month,and 3 months of treatment,and the difference was statistically significant(P<0.05).After treatment,the level of serum thyroid stimulating hormone(TSH)in the observation group was higher than that in the control group,while the levels of serum free thyroid hormone(FT4)and free triiodothyronine(FT3)were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Patients with hyperthyroidism complicated with leukopenia treated with Eleven Flavor Shenqi tablets on the basis of methimazole can improve their clinical efficacy,reduce traditional Chinese medicine syndrome scores,increase white blood cell counts,and enhance thyroid function.