Analysis of the Factors Influencing the Immunological Failure of Highly Active Antiretroviral Therapy in AIDS Patients
LIU Pingqing
ZHOU Gangfeng
HU Diangui
YANG Xiaoqin
Abstract：Objective To explore the factors influencing the immunological failure of highly active antiretroviral therapy(HAART)in acquired immunodeficiency syndrome(AIDS)patients.Methods Select 98 AIDS patients who received HAART at the Fifth People's Hospital of Ganzhou from May 2020 to January 2023,collect clinical data of the subjects,and analyze the factors affecting the immunological failure of HAART in AIDS patients.Results Among 98 AIDS patients who underwent HAART,27 cases(27.55%)had immunological failure and 71 cases(72.45%)had successful immune reconstitution;Multivariate logistic regression analysis showed that:age≥60 years old,injection drug infection,combined with other infections,time from diagnosis to initiation of treatment≥12 months,baseline cluster differentiation antigen(CD)4+T lymphocyte count<200 μL-1,poor/moderate medication compliance were the risk factors for HAART immune failure in AIDS patients(P<0.05),and antiviral therapy with integrase was the protective factor(P<0.05).Conclusion The proportion of HAART immune failure in AIDS patients is high,which is affected by age,route of infection,combined with other infections,the time from diagnosis to the start of treatment,medication regimen,medication compliance,and baseline CD4+T lymphocyte count.
Keywords：Acquired immunodeficiency syndromeHighly active antiretroviral therapyImmunological failureCluster differentiation antigen 4+T lymphocyte count
Publication Date：2024-10-16
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 26-29 )