Clinical Study on the Treatment of Mild-moderate Neonatal Respiratory Distress Syndrome by Heated Humidified High-flow Nasal Cannula
LIU Rongtian
CAI Yunxiang
MAO Jinmei
SHEN Zixuan
LONG Qi
BAI Yuxin
Abstract：Objective To investigate the efficacy and safety of heated humidified high-flow nasal cannula(HHHFNC)for the treatment of mild-to-moderate neonatal respiratory distress syndrome(RDS).Methods A total of 93 premature infants with mild to moderate RDS admitted to the neonatal intensive care unit of the Second People's Hospital of Shenzhen from January 2022 to December 2023 were selected as the research objects.According to the random number table method,the patients were divided into HHHFNC group(47 cases)and nasal continuous positive airway pressure(NCPAP)group(46 cases),and the clinical treatment effects,blood gas indicators,and incidence of complications were compared between the two groups.Results Compared with the NCPAP group,the total oxygen therapy time and non-invasive ventilation time of preterm infants in HHHFNC group were shortened,and the number of apneas within 24 hours was reduced,but the difference was not statistically significant(P>0.05).There was no significant differences in mechanical ventilation rate within 72 hours,hospitalization length and pulmonary surfactant(PS)usage rate between the two groups(P>0.05).There was no significant differences in hydrogen ion concentration index(pH),arterial oxygen partial pressure(PaO2),arterial carbon dioxide partial pressure(PaCO2)and lactic acid(Lac)between the two groups after 12 hours of treatment(P>0.05).There was no statistically significant difference in the incidence of air leakage syndrome,intraventricular hemorrhage(IVH),bronchopulmonal dysplasia(BPD),necrotizing enterocolitis(NEC),feeding intolerance(FI),early-onset sepsis(EOS),abdominal distension and pulmonary hemorrhage between the two groups(P>0.05).The incidence of nasal injury in HHHFNC group was significantly lower than that in NCPAP group(6.38%vs 26.09%),and the difference was statistically significant(P<0.05).Conclusion As an initial non-invasive respiratory support model for mild to moderate neonatal ARDS,HHHFNC has comparable clinical efficacy to NCPAP,without increasing the incidence of complications,and can significantly reduce the incidence of nasal injury.
Keywords：Respiratory distress syndromeHeated humidified high-flow nasal cannulaNasal continuous positive airway pressurePreterm infants
Publication Date：2024-10-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1-5 )