Drug Resistance and Influencing Factors of 1077 Cases of Mycobacterium Tuberculosis in Maoming Area from 2022 to 2023
CHEN Heyong
YE Xiaoyi
PAN Yuemei
LIANG Jinfeng
Abstract：Objective The drug resistance of 1077 cases of Mycobacterium tuberculosis in Maoming area from 2022 to 2023 was analyzed,and the influencing factors of drug resistance were analyzed.Methods A total of 1077 sputum samples collected from three counties of the Mycobacterium tuberculosis drug resistance monitoring project in Maoming from 2022 to 2023 were selected as the research object.All samples were confirmed to be positive for Mycobacterium tuberculosis by sputum culture.The drug resistance of Mycobacterium tuberculosis and the influencing factors of drug resistance were analyzed.Results In a cohort of 1077 sputum samples,the monotherapy resistance rate was higher than the polytherapy resistance rate and the multidrug-resistant rate during the period of 2022-2023.Similarly,in both 2022 and 2023,the monotherapy resistance rate was also higher than the polytherapy resistance rate and the multidrug-resistant rate,with statistically significant differences(P<0.05).In the distribution of drug resistance types in 2022,the top four drugs were Streptomycin(SM),Isoniazid(INH),Rifampicin(RFP),and Ethambutol(EMB),all of which are first-line anti-tuberculosis agents.In 2023,the top six drugs in the distribution of drug resistance types were SM,INH,RFP,and Ofloxacin(OFLX),Levofloxacin(LFX),and Moxifloxacin(MFX),including three first-line and three second-line anti-tuberculosis drugs.The overall distribution of drug resistance types from 2022 to 2023 indicated that the top six drugs were SM,INH,RFP,OFLX,LFX,and MFX,encompassing three first-line and three second-line anti-tuberculosis drugs.The incidence of drug resistance in retreatment patients(19.23%)was higher than that in non-drug-resistant patients(11.15%),and the difference was statistically significant(P<0.05).Conclusion The monotherapy resistance rate accounted for a higher proportion than the polytherapy resistance rate and the multidrug-resistant rate in Mycobacterium tuberculosis in the Maoming area from 2022 to 2023,with a higher resistance to drugs such as SM and INH.Retreatment is identified as a factor influencing patient drug resistance.
Keywords：Mycobacterium tuberculosisMonotherapy resistancePolytherapy resistanceMultidrug resistanceMaoming area
Publication Date：2024-09-16
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 29-32 )