Factors Influencing Hyperuricemia in Obese Children and Its Relationship with Body Composition

WANG Weihong; QIAO Yanling; XU Lingling; XUE Tao; JIN Jing; LI Mingjing

doi:10.16458/j.cnki.1007-0893.2023.22.002

Abstract：Objective To study the clinical factors influencing the occurrence of hyperuricemia in obese children and the relationship between uric acid level and body composition in obese children.Methods A total of 171 children diagnosed with simple obesity in the pediatric outpatient department and inpatient department of General Hospital of Ningxia Medical University from January 2018 to December 2022 were retrospectively analyzed.They were divided into hyperuricemia children and non-hyperuricemia children according to fasting blood uric acid level,and the differences in clinical data and body composition between the two groups were compared.Univariate and multivariate analysis was performed,and the correlation between uric acid level and other observational indicators in obese children was analyzed.Results Multivariate logistic regression results showed that the increase of body fat percentage,creatinine,blood calcium,blood phosphorus and alkaline phosphatase indexes were the independent risk factors for hyperuricemia in obese children,and the increase level of 25-hydroxyvitamin D was a protective factor for hyperuricemia in obese children(P＜0.05).The uric acid level in obese children was positively correlated with visceral fat area,body fat percentage,blood calcium,creatinine and alkaline phosphatase(r＞0,P＜0.01).Conclusion In obese children with the same body mass index,the higher the percentage of body fat and the area of visceral fat,the more likely to develop hyperuricemia.In addition,increased levels of creatinine,serum calcium,serum phosphorus and alkaline phosphatase were the risk factors for hyperuricemia in obese children,and increased level of 25-hydroxyvitamin D were the protective factors.