Clinical Distribution and Drug Resistance Analysis of Klebsiella Pneumoniae in Xishuangbanna Area from 2013 to 2022

LIU Wei; LI Tingting

doi:10.16458/j.cnki.1007-0893.2023.20.004

Abstract：Objective To analyze the clinical distribution and drug resistance of Klebsiella pneumoniae in Xishuangbanna area from 2013 to 2022.Methods From January 2013 to December 2022,5117 strains isolated from urine,sputum,blood and secretions from Xishuangbanna Dai Autonomous Prefecture People's Hospital were selected for retrospective analysis of the distribution and drug resistance of Klebsiella pneumoniae.Results A total of 5117 strains of Klebsiella pneumoniae were detected during the study,and the sputum with the highest proportion was 3886 strains,accounting for 75.90％.The detection rate of wound secretions,urine,blood,pus and joint effusion showed an increasing trend year by year.In terms of drug resistance,the resistance rate of Klebsiella pneumoniae to piperacillin,amoxicillin/clavulanate,cefoperazone/sulbactam,ceftazobacillin/piperacillin/tazobactam increased year by year from 2013 to 2016,decreased in 2017,and gradually increased from 2018 to 2020.The resistance in 2018-2020 was higher than that in 2017,decreased in 2021,and increased again in 2022.From 2013 to 2019,the resistance rate of Klebsiella pneumoniae to amtroenem and meropenem basically showed a gradually increasing trend,and in 2020,amtroenem resistance began to decline.The resistance rate of cefepime increased year by year from 2013 to 2018,and decreased from 2019 to 2022 compared with 2018.The lowest drug resistance rate was tigecycline,followed by amikacin.Conclusion From 2013 to 2022,Klebsiella pneumoniae in Xishuangbanna area caused an increasing trend of infections outside the respiratory tract year by year,and the phenomenon of drug resistance was relatively serious,but it improved in 2019-2022.Clinical supervision of rational use of antibiotics should continue to be strengthened to reduce the generation and spread of drug-resistant strains.