Comparison of the Efficacy and Safety of Sodium Valproate and Levetiracetam in the Treatment of Children with Epilepsy

YAN Caijin; WANG Yanzu; YANG Mei

doi:10.16458/j.cnki.1007-0893.2023.17.007

Abstract：Objective To compare the therapeutic effect and safety of sodium valproate and levetiracetam in the treatment of pediatric epilepsy.Methods 120 children with epilepsy admitted to Xinglin Branch of the First Affiliated Hospital of Xiamen University were selected from January 2019 to September 2022 and were randomly divided into a control group and an observation group,with 60 cases in each group.The control group was treated with sodium valproate and the observation group was treated with levetiracetam.The epileptic seizure frequency,electroencephalogram frequency band power before and after treatment,cognitive ability[Wechsler intelligence scale for children(WISC)]and occurrence of adverse reactions were compared between the two groups of children.Results After medication,the epileptic seizure frequency in the two groups was decreased compared with that before medication,and the frequency in the observation group was less than that in the control group,the differences were statistically significant(P＜0.05).The electroencephalogram spike wave count and δ and θ frequency band powers were decreased while a and βfrequency band powers were increased after treatment compared with those before medication,and the electroencephalogram spike wave count in the observation group was lower than that in the control group,the differences were statistically significant(P＜0.05).After medication,the speech score,operation score and total score in the observation group were higher compared with those in the control group,the differences were statistically significant(P＜0.05).The total incidence rate of adverse reactions was lower in the observation group compared to control group,the difference was statistically significant(P＜0.05).Conclusion Levetiracetam and sodium valproate have therapeutic effects in the treatment of children with epilepsy,but they can control the onset of disease and relieve the cognitive function damage,with high safety.