Research progress on the regulatory mechanism of MYH9 in intestinal epithelial cells and related diseases
XIA Yu
DONG Min
WU Jinkui
LI Mengbin
Abstract：Myosin heavy chain 9(MYH9)serves as a fundamental regulator of the intestinal epithelial cytoskeletal architecture.Through its coordinated control of cytoskeletal dynamics and intercellular junction organi-zation this molecular motor protein actively maintains epithelial barrier integrity while fine-tuning intestinal stem cell homeostasis-functions that demonstrate distinct dose-responsive characteristics.Under pathological stimuli,MYH9 manifests a context-dependent"double-edged sword"behavior.In inflammatory bowel disease,while com-plete MYH9 ablation compromises barrier function and amplifies inflammatory responses,its partial inhibition para-doxically enhances epithelial repair through activation of regenerative signaling cascades.During colorectal carcino-genesis,MYH9 fuels tumor progression by orchestrating MAPK/AKT signaling networks and synergizing with autophagy-related protein ATG9B to facilitate focal adhesion maturation.Furthermore,in pre-malignant conditions like intestinal metaplasia,MYH9 contributes to β-catenin pathway activation,thereby accelerating malignant trans-formation.This comprehensive review delineates the multifaceted regulatory networks governed by MYH9 in intestinal physiology and pathology,while proposing future investigative directions.Deciphering the context-specific function-ality of MYH9 will not only advance targeted therapeutic development but also illuminate its promising utility as a liquid biopsy biomarker for gastrointestinal disorders.
Keywords：myosin heavy chain 9cytoskeletonintestinal epithelial cellsinflammatory bowel diseasecolorectal cancer
Publication Date：2026-02-25
Online Publishing Date：2026-03-18(First online date of this platform, not the publication date of the document)
Pages：8( 706-713 )