The influence of pressure regulated volume controlled ventilation mode on respiratory mechanics,myo-cardial injury and postoperative pulmonary complications in patients undergoing cardiac valve surgery
BU Lin
HU Shuqun
CHAO Yali
ZHANG Shengnan
ZHOU Min
XU Huilin
Abstract：Objective To explore the value of pressure regulated volume-controlled ventilation mode(PRVC)in cardiac valve surgery based on respiratory mechanics,myocardial injury and postoperative pulmonary complications.Methods A prospective study included patients admitted to the affiliated Hospital of Xuzhou Medical University for elective cardiac valve replacement or repair from January 2024 to October 2025.After strict inclusion and exclusion criteria,a total of 100 cases were finally enrolled.Patients were assigned to the PRVC group(n=50)and the control group(n=50,volume-controlled ventilation mode)in a 1∶1 ratio by stratified block randomization.The respiratory mechanics and oxygenation status of the two groups at different times after surgery were compared.The levels of creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),hypersensitive troponin T(hs-cTnT),and N-terminal pro-brain natriuretic peptide(NT-proBNP)before and after surgery were determined.The occurrence of pulmonary complications within 7 days after surgery was recorded.Results At different time points,the Ppeak,Pplat and △P in the PRVC group were all lower than those in the control group,while Cdyn was higher,with intergroup and time effects(P<0.05),and with an interaction effect on Ppeak(P<0.05).At different time points,the PRVC group had higher PaO2 and OI,while lower RI and PA-aO2 were lower,with intergroup and time effects(P<0.05),among which there was an interaction effect of PaO2 and PA-aO2(P<0.05).At 6 hours and 24 hours after surgery,the levels of CK-MB,LDH,hs-cTnT and NT-proBNP in both groups were higher than those before surgery in the same group,and those in the PRVC group were lower.There were intergroup,time and interaction effects(P<0.05).The extubation time,ICU stay time and total hospital stay in the PRVC group were shorter(P<0.05),and the total incidence of postoperative pulmonary complications was significantly lower(P<0.05).Conclusions The PRVC mode used in cardiac valve surgery has less impact on respiratory mechanics and oxygenation than the VCV mode,has a significant lung-protective effect,can reduce myocardial injury and decrease pulmonary complications.
Keywords：cardiac valve surgeryventilation modepressure regulated volume-controlled ventila-tionvolume-controlled ventilationlung protectionrespiratory mechanics
Publication Date：2026-02-10
Online Publishing Date：2026-02-07(First online date of this platform, not the publication date of the document)
Pages：10( 531-540 )