Research progress and targeted therapeutic strategies of the SIRT1 pathway in adipose tissue for improv-ing obesity and insulin resistance
XUE Tingzheng
LIANG Fengxia
HUANG Liuyang
WANG Yayuan
SONG Yanjuan
Abstract：Silent mating type information regulation 2 homolog 1(SIRT1),a highly conserved NAD⁺-dependent deacetylase,is widely expressed in adipose tissue and plays a critical role in the pathogenesis of obesity and insulin resistance(IR).In adipose tissue,SIRT1 ameliorates obesity and related metabolic disorders through multiple mechanisms,including suppression of inflammatory responses,regulation of lipid metabolism,promotion of adipose browning and angiogenesis,and restoration of insulin signaling pathways.Targeted delivery of the SIRT1 agonist resveratrol(Res)to adipose tissue further enhances its therapeutic efficacy against obesity and IR.This article systematically reviews the molecular basis of SIRT1's structure,along with its physiological functions across various organ systems,provides a comprehensive elucidation of its multi-target regulatory network in adipose tissue in the context of obesity and IR,and summarizes various adipose-targeting delivery strategies for SIRT1 agonists,with a focus on Res.The aim is to offer new perspectives and research directions for the treatment of metabolic diseases.
Keywords：obesityinsulin resistancesilent information regulator 2 homolog 1targeted therapy
Publication Date：2026-02-10
Online Publishing Date：2026-02-07(First online date of this platform, not the publication date of the document)
Pages：8( 455-462 )