Evaluation value of sCD163,SHR,pro-ADM,PTX3 combined with score of chest CT on the condition and prognosis of elderly patients with stroke-related pneumonia

JIAO Jianhua; MA Ruixue; GU Honghong; WU Xing; CAO Xiuli

doi:10.3969/j.issn.1006-5725.2026.03.012

Abstract：Objective To explore the evaluation value of soluble CD163(sCD163),stress hyperglycemia ratio(SHR),adrenomedullin precursor(pro-ADM),and pentraxin 3(PTX3)in combination with the score of chest computed tomography(CT)in elderly patients with stroke-related pneumonia.Methods A total of 112 elderly patients with stroke-related pneumonia who were admitted to our hospital between March 2023 and March 2025 were selected as the research subjects.After 3 months of treatment,they were divided into the good prognosis group(77 cases)and the poor prognosis group(35 cases).Additionally,they were classified into the mild group(36 cases),the moderate group(45 cases),and the severe group(31 cases)according to the severity of the patients'illness.The serum levels of sCD163,SHR,pro-ADM,and PTX3,as well as chest CT scores,were com-pared among the groups.Pearson correlation analysis was used to assess the relationships.The poor prognosis group was defined as positive and the favorable prognosis group as negative.Then,the receiver operating characteristic(ROC)curve was plotted to evaluate the predictive value,and the area under the curve(AUC)was obtained.Results The levels of serum sCD163,SHR,pro-ADM,PTX3,and the chest CT score in the severe group were higher than those in the moderate and mild groups,and the levels in the moderate group were higher than those in the mild group(P<0.05).Inter-group comparisons between the poor prognosis group and the good prognosis group revealed that the levels of serum sCD163,SHR,pro-ADM,PTX3,and the chest CT score were higher in the poor prognosis group(P<0.05).Pearson correlation analysis showed that the levels of serum sCD163,SHR,pro-ADM,and PTX3 were positively correlated with the chest CT score(r=0.775,0.615,0.825,0.866,P<0.05).The levels of serum sCD163,SHR,pro-ADM,PTX3,the chest CT score,and the NIHSS score were positively correlated(r=0.682,0.793,0.847,0.805,0.762,P<0.05).The ROC analysis showed that the AUC value of the combined detection of the levels of serum sCD163,SHR,pro-ADM,and PTX3 and the chest CT score in predicting the prognosis of elderly patients with stroke-related pneumonia was 0.903,which was higher than that of each individual index(0.803,0.758,0.786,0.787,and 0.752,P<0.05).Conclusion Serum levels of sCD163,SHR,pro-ADM,and PTX3,along with chest CT scores,were associated with the condition and progno-sis of elderly patients with stroke-related pneumonia.Moreover,the combined detection of these five indicators was more valuable in predicting the prognosis of elderly patients with stroke-related pneumonia.