The analysis of the myocardial protective effect of lidocaine in intraoperative circulatory arrest during beating heart mitral valve replacement surgery
QIN Fuxing
ZHANG Chunying
ZHAO Mingyuan
HUANG Zehan
Abstract：Objective To investigate the myocardial protective effects and clinical value of lidocaine in cardiopulmonary bypass(CPB)non-arrested(beating-heart)mitral valve replacement surgery.Methods A total of 50 patients who underwent CPB beating-heart mitral valve replacement between January 2023 and September 2025 were randomly divided into two groups:Group A(lidocaine+beating-heart group)and Group B(beating-heart only group).The two groups received identical anesthesia induction and maintenance protocols.However,Group A additionally received an intravenous infusion of lidocaine at 1.5 mg/kg 10 minutes before anesthesia induction,followed by continuous infusion at a rate of 1.5 mg/(kg·h)until the end of surgery.Group B received only the beating-heart surgical technique without lidocaine.Plasma levels of high-sensitivity cardiac troponin T(TNT-HS),myoglobin(MYO),creatine kinase(CK),and creatine kinase-MB(CK-MB)were measured preoperatively(T0),at 6 hours postoperatively(T1),and at 12 hours postoperatively(T2).Results Compared with Group B,Group A showed significantly lower plasma levels of TNT-HS,MYO,CK,and CK-MB at T1 and T2(P<0.05).In both groups,these markers were significantly elevated at T1 and T2 compared with T0(P<0.05).Conclusion Lidocaine demonstrates significant myocardial protection during on-pump beating-heart mitral valve replacement surgery,effectively suppresses hemodynamic fluctuations during endotracheal intubation,and reduces the incidence of perioperative ventricular arrhythmias.
Keywords：lidocainemyocardial protectionbeating-heartmitral valve replacementextracor-poreal circulation
Publication Date：2026-02-10
Online Publishing Date：2026-02-07(First online date of this platform, not the publication date of the document)
Pages：7( 425-431 )