Mechanisms and clinical prospects of intravenous lidocaine for pain management in rheumatoid arthritis
WU Ting
XIA Mingzhong
YU Xiangdi
Abstract：Rheumatoid Arthritis(RA)is an autoimmune disease,with pain being its primary symptom.The mechanisms underlying RA pain involve both inflammatory and neuropathic components.Lidocaine,a classic amido-type local anesthetic,has gained widespread application in treating inflammatory and neuropathic pain due to its analgesic,anti-inflammatory,and immunomodulatory properties when administered intravenously.Given the exact match between the pathogenesis of RA pain and the pharmacological actions of intravenous lidocaine,this review explores the therapeutic potential of intravenous lidocaine infusion for RA pain.It aims to offer new insights into the clinical application of intravenous lidocaine for managing RA-related pain.
Keywords：rheumatoid arthritislidocaineintravenousinflammationneuropathic pain
Publication Date：2026-02-10
Online Publishing Date：2026-02-07(First online date of this platform, not the publication date of the document)
Pages：8( 355-362 )