Expression correlation of PD-L1 and Her-2 in invasive urothelial carcinoma and their impact on prognosis

LI Wen; HUANG Haisheng; HUANG Bin; HAN Li

doi:10.3969/j.issn.1006-5725.2026.02.004

Abstract：Objective To investigate the expression correlation of PD-L1 and Her-2 in invasive urothelial carcinoma(IUC)and their impact on patient prognosis,providing a basis for precise stratified treatment and prog-nostic evaluation.Methods A total of 60 IUC patients were included from May 2021 to May 2024.Immunohisto-chemistry was used to detect the expression levels of Her-2 and PD-L1 in tumor tissues.The correlation between their expressions and clinicopathological parameters(tumor differentiation grade,TNM stage,lymph node metastasis,etc.)was analyzed.Kaplan-Meier method and Log-rank test were used to compare progression-free survival(PFS)and overall survival(OS)among patients with different expression statuses.Cox proportional hazard regression model was applied to identify independent prognostic risk factors.Additionally,the diagnostic efficacy of combined Her-2 and PD-L1 detection for poor prognosis was evaluated.Results The positive rate of Her-2 was 38.33%(23/60),and the high expression rate of PD-L1 was 41.67%(25/60).Both expressions were positively correlated with low tumor differentiation(r=0.360/0.280,P<0.05)and clinical stage Ⅲ—Ⅳ(r=0.395/0.325,P<0.05).Multi-variate analysis revealed that Her-2 positivity(HR=1.878,P=0.042)and high PD-L1 expression(HR=1.822,P=0.039)were independent risk factors for poor prognosis.The AUC of combined Her-2 and PD-L1 detection was 0.830(P<0.001),with a sensitivity of 82.14%and specificity of 81.25%,which was significantly better than single indicators(P<0.05).Conclusions Her-2 positivity and high PD-L1 expression are independent risk factors for tumor progression and poor prognosis in IUC patients.Combined detection of the two can improve the efficacy of prognostic evaluation and provide a new biomarker combination for precise stratified treatment of IUC.