Application of CT perfusion parameters and serum CEA/AFP in monitoring post-TACE recurrence in pri-mary hepatocellular carcinoma
LI Pengzheng
CHENG Baoguo
LIU Jinzhan
LI Weixing
Abstract：Objective To investigate the application of CT perfusion(CTP)parameters,carcinoembryonic antigen(CEA),and alpha-fetoprotein(AFP)in monitoring recurrence after transcatheter arterial chemoemboliza-tion(TACE)in patients with primary hepatocellular carcinoma(HCC).Methods A retrospective analysis was conducted on 203 HCC patients who underwent TACE at the hospital from September 2022 to September 2023.CTP parameters[blood flow(BF),blood volume(BV),hepatic arterial perfusion index(HAI),portal venous perfusion(PVP)],CEA,and AFP levels were measured before and one month after TACE.Patients were followed up for one year and divided into recurrence and non-recurrence groups based on tumor status.Differences in BF,BV,HAI,PVP,CEA,and AFP levels between the two groups were compared.Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive value of these indicators for post-TACE recurrence,and logistic regression was used to analyze influencing factors.Results Compared with pre-TACE levels,BF,BV,HAI,CEA,and AFP decreased one month after TACE,while PVP increased(P<0.05).Among the 203 patients,75(36.95％)experienced recurrence,while 128(63.05％)remained recurrence-free.Compared with the non-recurrence group,the recurrence group exhibited higher BF,BV,HAI,CEA,and AFP levels and lower PVP(P<0.05).The AUC values for BF,BV,HAI,PVP,CEA,and AFP in predicting recurrence were 0.771,0.787,0.787,0.735,0.771,and 0.795,respectively.The combined detection of these indicators yielded an AUC of 0.968(P<0.05).Logistic regression identified BF,BV,HAI,PVP,CEA,and AFP as independent risk factors for post-TACE recurrence(P<0.05).Conclusion CTP combined with serum tumor markers can effectively predict early recurrence in HCC patients after TACE.
Keywords：primary hepatocellular carcinomatranscatheter arterial chemoembolizationCT perfu-sion imagingcarcinoembryonic antigenalpha-fetoproteinrecurrenceinfluencing factors
Publication Date：2026-01-25
Online Publishing Date：2026-01-28(First online date of this platform, not the publication date of the document)
Pages：9( 176-184 )