Research progress on the treatment of femoral skull necrosis by extracellular vesicles from bone marrow mesenchymal stem cells
LI Aiqiang
ZHAO Ning
ZHANG Xusheng
LIU Haiping
Abstract：Osteonecrosis of the femoral head(ONFH)is a disabling orthopedic disease,pathologically characterized by progressive collapse of the femoral head accompanied by destruction of the trabecular and articular cartilage structures,leading to hip joint pain and progressive functional impairment.Bone marrow mesenchymal stem cell-derived extracellular vesicles(BMSC-EVs)show great promise in tissue repair and regeneration,with low immunogenicity and tumorigenicity,and play roles in osteogenesis,angiogenesis,and immunomodulation.This review summarizes the therapeutic effects and underlying mechanisms of BMSC-EVs in ONFH,providing a theoretical basis for its treatment.
Keywords：femoral head necrosisbone marrow mesenchymal stem cellsextracellular vesiclesbone repair
Publication Date：2025-12-10
Online Publishing Date：2025-12-19(First online date of this platform, not the publication date of the document)
Pages：7( 3631-3637 )