Research progress of omics technologies in thyroid dysfunction
ZHANG Wenyan
SHAO Feifei
TIAN Limin
Abstract：Thyroid dysfunction(TD)is a prevalent disorder of the endocrine system.Owing to its non-specific clinical symptoms and the limitations inherent in current diagnostic approaches,there is a pressing need to further investigate its underlying pathogenesis and identify novel biomarkers.As a pivotal component of systems biology,omics technologies offer a promising avenue for uncovering the molecular mechanisms of TD by integrating high-throughput data.This thesis presents a comprehensive review of recent advancements in genomics,transcriptomics,proteomics,metabolomics,lipidomics,and multi-omics research related to TD.It examines genetic variations and epigenetic regulatory mechanisms from multiple molecular levels,including DNA,RNA,proteins,and metabolites.Furthermore,it elucidates the metabolic disturbances associated with TD and the modes of action of relevant therapeutic agents,contributing to the development of potential biomarkers and drug targets for early detection and intervention.By synthesizing findings across various omics platforms,this thesis aims to delineate the complex network interactions underlying TD and to provide valuable insights and strategies for future clinical management,as well as personalized diagnosis and treatment.
Keywords：thyroid dysfunctiongenomicstranscriptomicproteomicsmetabolomicslipido-mics
Publication Date：2025-10-25
Online Publishing Date：2025-11-05(First online date of this platform, not the publication date of the document)
Pages：9( 3288-3296 )