The correlation between serum P-Tau181,GGT,SIRT1 and sleep disorders in patients with cerebral small vessel disease
ZHANG Li
FU Yunting
Abstract：Objective To explore the correlation between serum phosphorylated Tau protein-181(P-Tau181),gamma glutamyl transpeptidase(GGT),silent information regulator 1(SIRT1)and sleep disorders in patients with cerebral small vessel disease.Methods A total of 156 patients with cerebral small vessel disease(CSVD)were divided into a sleep disorder group(PSQI≥10)and a normal sleep group(PSQI<10)based on the Pittsburgh Sleep Quality Index(PSQI)scores.Serum levels of P-Tau181,GGT,and SIRT1 were compared between the two groups,and the predictive value of these biomarkers for the development of sleep disorders in CSVD patients was analyzed.Results Among 156 patients with cerebral small vessel disease(CSVD),52(33.33%)were diag-nosed with sleep disorders,and their Pittsburgh Sleep Quality Index(PSQI)scores were significantly higher than those of the normal sleep group(P<0.05).The serum levels of P-Tau181,GGT,and SIRT1 in the sleep disorder group were elevated compared to the normal sleep group(P<0.05).Positive correlations were observed between PSQI scores and P-Tau181,GGT,and SIRT1 levels(P<0.05).The areas under the curve(AUC)for predicting sleep disorders in CSVD patients using individual biomarkers(P-Tau181,GGT,SIRT1)and their combined prediction were 0.672,0.742,0.749,and 0.843,respectively.Conclusion The abnormal expression of P-Tau181,GGT,and SIRT1 is associated with sleep disorders in patients with cerebral small vessel disease.
Keywords：cerebral small vessel diseasesleep disordersP-Tau181GGTSIRT1
Publication Date：2025-06-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1867-1872 )