Research progress on circadian rhythm genes regulating digestive system tumors and the intervention of traditional Chinese medicine
SUN Shuo
ZHANG Wenjie
ZHAO Yi
SUN Youzhi
Abstract：Circadian rhythms,a result of the long-term evolution of organisms adapting to the Earth′s environment,play a crucial regulatory role in biological activities.Disruptions in circadian rhythms have been iden-tified as potential carcinogenic risk factors,closely linked to the pathological states of digestive system diseases,and significantly contribute to the occurrence and progression of digestive system tumors.These rhythms not only influence the regulation of cell cycles,proliferation,and apoptosis of tumor cells but also profoundly affect their migratory abilities,immune functions,and drug resistance.This article focuses on the specific regulatory mechanisms of circadian rhythm genes in relation to digestive system tumors and comprehensively summarizes research findings on the anti-tumor effects of traditional Chinese medicine targeting these circadian clock genes.The aim is to provide new avenues for target selection and prognostic evaluation in the treatment of digestive system tumors.
Keywords：circadian rhythmcircadian clock genesdigestive system tumorstraditional Chinese medicinemechanism
Publication Date：2025-03-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 648-656 )