Advances in the role and mechanism of ISG15 in malignant tumours of the gastrointestinal tract
JIANG Ping
LUO Xiaoqin
ZHAI Shaoqian
CAO Chengzhu
SU Zhanhai
Abstract：Interferon-stimulating gene 15(ISG15),an ubiquitin-like molecule belonging to the superfamily of ubiquitin-like proteins,is highly expressed in various malignant tumors and induced by type Ⅰ interferon.How-ever,its specific regulatory mechanism remains unclear.Numerous studies have demonstrated its close association with tumorigenesis and development.In this study,we provide a comprehensive review on the role of ISG15 protein in hepatocellular carcinoma,esophageal carcinoma,gastric carcinoma,colorectal carcinoma,and other cancers.Our aim is to identify new therapeutic targets for gastrointestinal malignancies and improve prognostic assessment.
Keywords：ISG15gastrointestinal malignant tumoursnew targets for the treatment
Publication Date：2024-12-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：11( 3394-3404 )