Predictive efficacy of free mitochondrial DNA and miR-146a expression in peripheral blood in assessing short term prognosis of sepsis
WU Haiyan
WANG Baoyu
JIA Baohui
Abstract：Objective To explore the value of free mitochondrial deoxyribonucleic acid(DNA)and micro ribonucleic acid(miRNA,miR)-146a expression in peripheral blood in assessing short-term prognosis of sepsis.Methods Totally 145 patients with sepsis admitted to the hospital from March 2021 to February 2023 were selected to detect the free mitochondrial DNA and miR-146a expression in peripheral blood.The incidence of poor prognosis after 28 days was counted,and the patients were then divided into poor prognosis group and good prognosis group.The general data and the free mitochondrial DNA and miR-146a expression in peripheral blood of the two groups were compared.Logistic regression analysis was used to explore the influencing factors of poor prognosis in patients.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive efficacy of free mitochondrial DNA and miR-146a expressionin assessing the short-term prognosis of sepsis.Results The incidence of poor short-term prognosis in the 139 patients who completed the study was 28.78％.Concurrent diabetes(OR=1.765,95％CI:1.181～2.637),acutephysiology and chronic health evaluation(APACHE Ⅱ)score(OR=1.972,95％CI:1.317～2.953),free mitochondrial DNA in peripheral blood(OR=2.416,95％CI:1.524-3.829),and miR-146a expres-sion(OR=2.462,95％CI:1.431～4.237)were risk factors for poor short-term prognosis of patients with sepsis(P＜0.05).The sensitivity,specificity and area under curve(AUC)of free mitochondrial DNA and miR-146a expression in peripheral blood to predict poor short-term prognosis were higher than those of APACHE Ⅱ score(P＜0.05),and the sensitivity and AUC of free mitochondrial DNA and miR-146a expressions in peripheral blood to predict poor short-term prognosis were higher than those of both alone(P＜0.05).Conclusions Free mitochondrial DNA and miR-146a expression in peripheral blood are related to poor short-term prognosis of sepsis.The efficacy of both of them in assessing poor short-term prognosis of sepsis is better than that of APACHE Ⅱ score,and their combined prediction efficacy is even better.
Keywords：mitochondriadeoxyribonucleic acidmicro ribonucleic acid-146asepsisprognosis
Publication Date：2024-12-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 3356-3361 )