Advances in research on optimal dialysate bicarbonate concentration for maintenance hemodialysis patients
WAN Jingfang
CHEN Kehong
Abstract：Metabolic acidosis is a prevalent complication in patients undergoing maintenance hemodialysis(MHD).The maintenance of acid-base balance in MHD patients primarily relies on the total alkali supply in the dialysate.Achieving an optimal concentration of dialysate bicarbonate(DBIC)is crucial to prevent metabolic acidosis before subsequent hemodialysis sessions while avoiding metabolic alkalosis after the current session.Inad-equate correction or overcorrection of pre-dialysis metabolic acidosis has been associated with unfavorable patient outcomes;however,there is currently a lack of guidelines or expert consensus regarding DBIC concentration.This study addresses the epidemiology of metabolic acidosis in MHD patients,explores the relationship between DBIC concentration and acid-base disorders,and discusses recent advancements in determining the ideal DBIC concentration,providing valuable insights for formulating scientifically sound and personalized DBIC dialysis prescriptions.
Keywords：maintenance hemodialysisdialysate bicarbonateartificial intelligencemetabolic acido-sismetabolic alkalosis
Publication Date：2024-09-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 2520-2524 )