Association of lipid variability with adverse cardiovascular events in STEMI patients after emergency per-cutaneous coronary intervention
XIE Wei
SU Zhenqi
Abstract：Objective Exploring the predictive value of blood lipid variability for adverse cardiovascular events in patients with acute ST segment elevation myocardial infarction(STEMI)after emergency percutaneous coronary intervention(PCI).Methods A total of 235 STEMI patients who underwent emergency PCI in our hospital from October 2020 to October 2022 were selected as the research objects.According to whether target lesion failure(TLF)occurred,the patients were divided into TLF group and control group Lipid variability[stan-dard deviation(SD),coefficient of variation(CV)and mean-independent coefficient of variation(VIM)]of the two groups were compared.Multivariate Cox regression analysis was used to explore the related factors of TLF in STEMI patients after emergency PCI,and receiver operating characteristic curve(ROC)was used to analyze the predictive value.Results Variability indexes of low-density lipoprotein(LDL),high-density lipoprotein(HDL)and lipoprotein a[LP(a)]in TLF group:LDL(SD),LDL(CV),LDL(VIM),HDL(SD),HDL(CV),HDL(VIM),LP(a)(SD),LP(a)(CV),LP(a)(CV)a)(VIM)were higher than those in control group,and the differences were statistically significant(P<0.05).The results of multivariate Cox regression analysis showed that LDL(SD),LDL(CV),LDL(VIM),HDL(SD),HDL(CV),HDL(VIM),LP(a)(SD),LP(a)(CV),LP(a)(VIM)were all risk factors for TLF in STEMI patients after emergency PCI(P<0.05).ROC curve analysis results showed that,LDL(SD),LDL(CV),LDL(VIM),HDL(SD),HDL(CV),HDL(VIM),LP(a)(SD),LP(a)(CV),LP(a)(VIM)have certain predictive value for TLF in STEMI patients after emergency PCI(AUC:0.790,0.805,0.833,0.766,0.795,0.816,0.773,0.782,0.798).Conclusion Lipid variability is associated with adverse cardiovascular events in STEMI patients after emergency PCI,and is an independent risk factor for TLF in STEMI patients after emergency PCI.
Keywords：lipid variabilitySTEMIPCIadverse cardiovascular events
Publication Date：2024-08-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 2121-2125 )