Analysis of factors influencing short-term adverse clinical outcome in cirrhotic patients with grade 2/3 ascites
WANG Qingqing
DING Jie
LI Haiwen
DONG Zhijian
WANG Yiying
LIU Siqi
CHANG Guoji
HUA Lijuan
CHEN Huayi
LI Shenghao
YANG Yongrui
Abstract：Objective To explore the factors influencing the short-term adverse clinical outcome in patients hospitalized with grade 2/3 cirrhosis ascites.Methods 82 patients with grade 2/3 cirrhosis ascites in Kunming Third People's Hospital from December 2021 to February 2023 were used as research objects.Demographic data and first clinical data were collected.The clinical outcomes of the patients within 90 days after admission were followed up.Influencing factors of adverse clinical outcome were investigated by single factor screening and binary logistic re-gression analysis,including hospitalization over 28 days,unplanned readmission within 28 days,and death within 90 days(including death within 28 days).Finally,the diagnostic efficacy of the influencing factors were judged by ROC curve.Results(1)MELD-Na score(OR = 1.087,95%CI:1.006～1.175)and GGT(OR = 1.004,95%CI:1.002～1.007)were independent risk factors for hospitalization longer then 28 days,unplanned readmission within 28 days of admission and death within 28 days,respectively,all P＜0.05.BUN was an independent risk factor for all three conditions,with an OR of 1.111(95%CI:1.005～1.227),1.115(95%CI:1.003～1.214)and 1.208(95%CI:1.057～1.382),all P＜0.05.(2)low serum chloride(OR = 0.875,95%CI:0.802～0.954)and low total CO2(OR = 0.821,95%CI:0.690～0.976)were independent riak factors for death within 90 days,all P＜0.05.(3)The area under ROC curve of BUN combined with GGT predicted death within 28 days was 0.891;The area under curve of serum chloride combined with total CO2 predicted death within 90 days was 0.821,P＜0.05.Conclusion BUN combined with GGT had better predictive value for death within 28 days,serum chloride combined with total CO2 had better predictive value for death within 90 days.
Keywords：cirrhosis ascitesblood urea nitrogenserum chloridetotal carbon dioxiderisk factors
Publication Date：2024-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1114-1120 )