MAPK improves intestional obstruction in pregnancy through inhibiting TLR4/Myd88/NF-κB pathway
GAO Fei
LI Jing
LI Hongjian
Abstract：Objective To investigate the effect of MAPK on intestinal obstruction during pregnancy.Methods A total of 105 SPF Wistar rats(female = 70 and male = 35)were selected.After placing all the rats in the same cage,33 female rats were pregnant,and 8 rats were assigned to the control group and the other 25 rats were used to established bowel obstruction model.A total of 24 rats were successfully modelled,which were divided into model group(n = 8),up-regulation group(n = 8),and down-regulation group(n = 8).Results Compared with the model group,MAPK expression,VIP,GAS,TNF-α,IL-6 levels,TLR4,Myd88,NF-κBmRNA were increased and MOT,IL-4,IL-10 levels were decreased in up-regulation group;MAPK expression,VIP,GAS,TNF-α,IL-6 levels,TLR4,Myd88,NF-κB mRNA were decreased and MOT,IL-4,IL-10 levels were increased in down-regulation group(P＜0.05).Conclusion MAPK down-regulation reduced inflammatory response and improved bowel obstruction in pregnancy,and the mechanism may be related to the inhibition of TLR4/Myd88/NF-κB pathway.
Keywords：intestinal obstruction during pregnancygastrointestinal functionmitogen-activated pro-tein kinaseToll-like receptor 4/myeloid differentiation factor 88/nuclear transcription factor-κB
Publication Date：2024-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1095-1100 )