The gender-specific effects on doses of remimazolam and quality of postoperative recovery in patients un-dergoing ambulatory arthroscopic surgery

TANG Lili; SUN Yue; LIU Xuesheng; LU Yao

doi:10.3969/j.issn.1006-5725.2024.08.007

Abstract：Objective To investigate the effects of gender on dosage of remimazolam and quality of recovery in patients undergoing ambulatory arthroscopic surgery at 24 hours postoperatively.Methods Fifty patients who underwent elective arthroscopic meniscus repair in a daytime surgery center were divided into two groups according to gender:25 males(group M)and 25 females(group F).The remimazolam dogages of loss of consciousness and anesthesia maintenance were recorded,and the effects of gender on the quality of recovery at 24 hours postopera-tively and sleepquality were observed by using QoR-15 scale and Athens Insomnia Scale(AIS).Results The doses of remimazolam at the time of loss of consciousness and anesthesia maintenance for patients were(0.13 and 0.15)mg/kg and 0.80(0.60 and 0.96)mg/(kg·h)in group M,and 0.14(0.12 and 0.16)mg/kg and 0.90(0.79 and 1.12)mg/(kg·h)in group F.There were no statistical differences in the doses of remimazolam between the two groups(P＞0.05).AIS scores did not differ on postoperative day one between the two groups(P＞0.05),but there was a statistically significant difference on final awakening earlier than expectation in the female patients(P＜0.05).Female patients had lower total QoR-15 scores and physiological comfort scores,and higher incidences of hypoten-sion and PONV than male patients(P＜0.05).Conclusions Gender had no significant effects on dosage of remima-zolam during anesthesia induction and anesthesia maintenance in the patients receiving daytime arthroscopy.Female patients had final awakening earlier than expectation,and male patients had higher quality of recovery at 24 hours postoperatively.