A randomized controlled study of remimazolam tosilate under bispectral index and bypass EtCO2 monitor-ing in daytime hysteroscopic surgery
ZHANG Junjie
YANG Xiaochun
LIU Zhuoyi
WU Ruoqiu
LI Ping
GUO Qulian
WANG E
Abstract：Objective To study the efficacy and safety of remimazolam tosilate in painless daytime hystero-scopic surgery.Methods A total of 300 patients(18～60 years,BMI 18.5～27 kg/m2,and ASA Ⅰ-Ⅱ)undergoing selected painless daytime hysteroscopic surgery were randomized into two groups.Group R received remimazolam tosilate at an initial dose of 0.2 mg/kg,and then single 0.05 mg/kg if needed according to bispectral index.Group P,according to the bispectral index,received propofol at an initial dose of 1.5～2 mg/kg,and single 0.5 mg/kg if needed.All the patients were intravenously given 5 μg sufentanil five minutes before hysteroscopy.The anesthesia-related indicators(anesthesia onset time,surgical duration,anesthesia recovery time,and time to leaving the operating room)and safety indexes(hypotension,hypoxia,nausea and vomiting,and doctor and patient satisfaction)were recorded.Results The incidence of hypotension and injection pain was significantly higher in group P(P＜0.01).There were no significant differences between the two groups in surgical duration,awakening time,time to leaving the operating room,nausea and vomiting,and patient satisfaction(P＞0.05).Conclusion Remimazolam can be used safely and effectively in painless daytime hysteroscopic surgery.
Keywords：daytime surgeryremimazolam tosilatepropofolhysteroscopyinjection painhypotension
Publication Date：2024-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1047-1051 )