Effects of the rheic acid on the expression of PPARγin diabetic rats′mesangial cells
DUAN Shufang
HU Jiang
Abstract：Objective To observe the Rhein acid′s effect on the rats′ mesangial cell(MsC)induced by high glucose(30 mmol/L),and to explore its mechanism for protection. Methods Using Rhein acid′s on MsC in-duced by high glucose. Cell survival rate was detected by Annexin V-FITC. BcL-2 and PPARγ level were deter-mined by RT-PCR. P-JNK and PPARγ level were determined by Western blot. Results Rhein acid could inhibit p-JNK,increase PPARγ′s expression in MsC induced by high glucose,and inhibit cell survival rate. Conclusion Rhein acid can alleviate inflammatory response of MsC induced by high glucose via regulating the expression of p-JNK and PPARγ,and improve islet cell function,as a result of protecting kidney function of DN.
Keywords：rheinmesangial cells of ratsp-JNKPPARγ
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1636-1639 )