Relationship between levels of indoxyl sulfate and severity of coronary artery disease

PAN Hailin; LI Fengjin; GUO Kai

doi:10.3969/j.issn.1006-5725.2018.03.011

Abstract：Objective Indoxyl sulfate (IS) is associated with endothelial damage, NF-κB activation and induces the development of atherosclerosis. The purpose of this study was to investigate the relationship between serum IS levels and the severity of coronary artery stenosis and the relationship among IS and various cardiovascular risk factors. Methods Serum IS concentrations were measured using ultra performance liquid chromatography in 191 consecutive patients presenting with stable angina. The associations between serum IS levels and angio-graphic indexes of the number of diseased vessels, modified Gensini scores and calcium scores were determined. Results Patients with significant coronary artery stenosis were found to have higher serum IS levels than those with normal coronary arteries. Multivariate analysis showed that serum IS levels were found to be independently associated with the presence and severity of coronary artery disease (CAD). Furthermore, statistically significant correlation was observed between the serum IS levels and age, Agatston calcium score, volume calcium score, modifed Gensini score, coronary lesions, coronary disease and Framingham-10 year risk score. Conclusions Se-rum IS levels are significantly higher in the presence of CAD and correlate with the severity of the disease and coro-nary atherosclerosis scores,which suggests that increased serum IS may be involved in the pathogenesis of coronary atherosclerosis.