Expression of IL-18 in sepsis-associated thrombocytopenia and its clinical significance
LI Jian
XU Hua
WANG Bing
WANG Yongqiang
Abstract：Objective To investigate the expression of IL-18 in severe sepsis and sepsis-associated throm-bocytopenia and explore its clinical significance.Methods Real-time polymerase chain reaction was applied to de-tect the expression of IL-18 miRNA in 28 samples of sepsis-associated thrombocytopenia patients and 32 samples of severe sepsis. The enzyme-linked immunosorbent assay was applied to detect the concentration of IL-18 in their plasma. Results The miRNA expression of IL-18 in the sepsis-associated thrombocytopenia group was higher than in the severe sepsis group(P=0.015).The concentration of IL-18 in the severe sepsis-associated thrombocyto-penia group were also higher than those in the severe sepsis group(P=0.034). Conclusion The expression level of IL-18 is related with the severity of thrombocytopenia in patients with sepsis and is likely to play an important role in the pathogenesis of sepsis-associated thrombocytopenia.
Keywords：IL-18sepsisthrombocytopenia
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 205-208 )