Expression and clinical analysis of snail in 41 patients with non small cell lung cancer
LU Rui
XIAN Lei
WU Guoyu
Abstract：Objective To study the expressions of snail mRNA and protein in human non-small cell lung cancer (NSCLC) and their correlations to patient clinical features.Methods Real-time fluores-cence quantitative PCR (qRT-PCR) and immunohistochemical were used to analyze the expressions of snail in a total of 41 pairs of NSCLC tissues,12 specimens of normal lung tissues.Results The expressions of snail mRNA in NSCLC tissues were significantly higher than the corresponding adjacent tissues (P ＜ 0.01).The expression rate of snail protein of NSCLC tissues (25/41) were significantly higher than that in adjacent tissues (2/41,P ＜ 0.01).There was no snail expression in non-cancerous lung tissues.The level of mRNA and protein in snail was associated with lymph node metastasis and clinical stage of non-small cell lung cancer (P ＜ 0.05).Conclusion The higher expression of snail may promote the metastasis of lung cancer.The expressions of snail are related to the development of human non-small cell lung cancer.
Keywords：non-small cell lung cancersnailqRT-PCRimmunohistochemistryclinical features
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3733-3736 )