Relationship between insulin resistance and inflammatory factors in rats with chronic intermittent hypoxia
Abstract：Objective:To investigate the relationship between insulin resistance and inflammatory factors ,adiponec-tin and leptin in intermittent hypoxia rats. Methods:30 male SD rats were randomly divided into two groups:nor-mal oxygen/ normal oxygen group ,2 weeks intermittent hypoxia group ,8 weeks intermittent hypoxia group ,10 rats in each group. The rats were divided into groups. Fasting blood glucose,fasting insulin,insulin resistance in-dex was calculated by steady-state model formula ,the simultaneous detection of total cholesterol and triglyceride , TNF-α,IL-6,IL-2,NF-κB,HIF-1,adiponectin and leptin,three groups were compared,and the analysis of the relationship between insulin resistance index and TNF-α,IL-6,IL-2,NF-κB,HIF-1,adiponectin and leptin. Re-sults:the total cholesterol,triglyceride,TNF-α,IL-6,IL-2,NF-κB,HIF-1,leptin,insulin resistance index were significantly higher in intermittent hypoxia rats than those in control group(P<0.05). HOMA-IR was positive-ly correlated with total cholesterol,triglyceride,NF-κB,HIF-1,IL-1,IL-6,TNF-α,leptin,and negatively cor-related with adiponectin(P<0.05). Conclusion:Insulin resistance in intermittent hypoxia rats may be related to the increase of inflammatory factors TNF-α,IL-6,IL-2,NF-κB,HIF-1,leptin and adiponectin. To investigate the re-lationship between insulin resistance and inflammatory factors in intermittent hypoxia rats.
Keywords：sleep apnea hypopnea syndromeinsulin resistanceinflammatory factorsadiponectinLeptin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1601-1604 )