The new applications of amplitude integrated electroencephalogram in an animal model of temporal lobe epilepsy
Abstract：Objective To explore the value of amplitude integrated electroencephalogram (aEEG) in an animal model of temporal lobe epilepsy for epileptiform discharges detection. Methods 4 young male adult rhesus monkeys received unilateral intra-amygdala kainic acid(2 μg/μL)injection for developing a chronic epilepsy condition. EEG was monitored punctually. EEG records were done by regular conventional EEG and aEEG simultaneously. Abnormal event in aEEG were located and studied retrospectively on their conventional EEG at the same period of time, aiming at judging the accuracy for its diagnosis of seizure. Results After exemption of abnormal events from poor contact, 23 aEEG events were recognized as abnormal. After conventional EEG analysis on the above 11 events, all proved to be seizure. Conclusions Seizure events could be distinguished easily in aEEG trend chart. In long-term EEG recordings, the application of aEEG could quickly locate the seizure events, thus results in a significant increase in efficiency.
Keywords：Temporal lobe epilepsyRhesus monkeyAmplitude integrated electroencephalogramAnimal model
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1405-1409 )