Collagen and angiogenesis related factors in different type of idiopathic interstitial pneumonia

doi:10.3969/j.issn.1006?5725.2017.05.010

Abstract：Objective To investigate and compare the expression of collagen and angiogenesis related factors in patients with idiopathic interstitial pneumonia(IIP)in different type of idiopathic interstitial pneumonia. Methods There were 187 consecutive IIP patients including 118 patients with idiopathic pulmonary fibrosis(IPF) and 69 patients with nIPF?IIP including non?specific interstitial pneumonia(NSIP,n=30),cryptogenic organizing pneumonia (COP,n = 29),respiratory bronchiolitis interstitial lung disease (RB?ILD,n = 10). The controls includes 38 males and 30 females. Bronchoalveolar lavage fluid(BALF)and serum were collected. The levels of pro?collagens I(PCI)and pro?collagensⅢ(PCⅢ),ENA?78 and IP?10 in BALF and serum were measured by ELISA assays. Results The levels of PC Ⅲ in BALF and serum were increased in patients with IPF and nIPF?IIP compared with controls(P<0.01),and PCⅢin IPF was much higher than in nIPF?IIP(P=0.00). PCI levels had no difference among three groups(P>0.05). The levels of ENA?78 in BALF were significantly higher in patients with IIP than controls(P<0.01),and with no significant difference between IPF and nIPF?IIP(P>0.05). The concentration of IP?10 in BALF were significantly lower in patients with IIP than controls(P<0.01),and patients with nIPF?IIP is lower than in IPF(P=0.049). In IIP patients,the concentrations of ENA?78 and IP?10 in BALF had a negative correlation(r=-0.378 P=0.02). In peripheral blood,the concentrations of ENA?78 and IP?10 had no significant difference among the group between IPF,nIPF?IIP and control(P > 0.05). Conclusions Collagen synthesis increase much more in patients with IPF than nIPF?IIP. angiogenesis activities are increased in patients with IIP.