Prediction of gestational diabetes mellitus in first trimester with body mass index, fasting blood glucose and glycosylated hemoglobin combined tests
CEN Li-wei
Abstract：Objective To study the clinical value of body mass index (BMI), fasting blood glucose (FPG)and glycosylated hemoglobin (HbA1c) combined tests for prediction of gestational diabetes mellitus (GDM) in first trimester. Methods 138 cases diagnosed as GDM and 133 cases of normal pregnant women were divided into study group and control group. The parameters of BMI , FPG and HbA1c were measured and compared. Results (1) BMI, FPG and HbA1c from study group were significantly higher than those from control group (P < 0.01). (2) The area under receiver operating characteristic curve (AUC) of BMI was 0.617 for predicting GDM, AUC of FPG was 0.700, and AUC of HbA1c was 0.684. When taking two of the optimal diagnostic cut-off values of BMI > 23.25, FPG > 4.25 L, HbA1c > 4.95% as screening method, AUC was 0.773. This method showed a diagnostic sensitivity of 73.3% and specificity of 82.4%. Conclusion BMI, FPG and HbA1c combined method in first trimester is valuable in predicting GDM.
Keywords：Gestational diabetes mellitusBody mass indexFasting blood glucoseGlycosylated hemoglobin
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3120-3122 )