Expression and clinical significance of androgen receptor in human epidermal growth factor receptor-2 enrich breast cancer
NI Jie
SHEN Li-jie
HUO Jun-jie
LI Man
JIANG Xi
YAO Xue-pin
ZHI Xiang-cheng
Abstract：Objective To investigate the expression of AR and its relationship with clinicopathological features in human epidermal growth factor receptor-2(Her-2) enrich breast cancer. Mehtods The expression of AR was detected by immunohistochemical staining in 102 patients with Her-2 enrich breast cancer. The relationship between AR expression and its clinicopathological characteristics was analyzed. Results The positive rate of AR expression was 75.5%. Patients in the positive group had a lower level of lymph nodes and Ki-67 value (P < 0.05). However, no significant differences of AR expression were observed in age, menopausal status, tumor size, histological grade, vessel invasion, P53 and PCNA (P > 0.05). Conclusion AR was highly expressed in Her-2 enrich breast cancer, which may be a potential target for treatment of Her-2 enrich breast cancer.
Keywords：Breast neoplasmAndrogen receptorHuman epidermal growth factor receptor-2 enrich breast cancer
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2854-2856 )