IL-4 induced proliferation in prostate cancer PC3 cells via regulating LDH-A expression
CAI Zhi-duan
CHEN Guo
FU Xin
YE Jian-heng
LI Bo-wei
JIANG Min-yao
ZHONG Wei-de
Abstract：Objective To study the effects of IL-4 in prostate cancer cells glycometabolism and proliferation. Methods We used IL-4 to treat PC3 cells, then tested the changes of LDH-A expression by RT-qPCR, Western Blot, CCK-8 and lactate production assay. Results Our data showed that IL-4 induced LDH-A up-expression in PC3 cells at mRNA and protein levels. Also, IL-4 promoted the proliferation activation and increased lactate production in PC3 cells. Conclusion IL-4 can strengthen the proliferation activation in PC3 cells by up-regulating LDH-A expression.
Keywords：IL-4LDH-Aprostate cancer cellsproliferation
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 516-519 )