Influence of CRRT on trough concentration of vancomycin in critically ill elderly patients
Abstract：Objective To elucidate the influence of continuous renal replacement therapy (CRRT) on trough concentration of vancomycin in critically ill elderly patients. Methods We detected the concentration of vancomycin in 48 critically ill elderly patients with/without CRRT 48 hours after receiving vancomycin treatment and reviewed the clinical characteristics of the patients. Results The trough concentration of CRRT group and non-CRRT group was (21.34 ± 10.74) mg/L and (29.01 ± 9.16) mg/L, respectively (t = 2.66, P = 0.01). In CRRT and non-CRRT group, the trough concentration of 15 ~ 20 mg/L were both 16.67% but that of < 15 mg/L was 37.50% and 4.17%, respectively, and that of > 20 mg/L was 45.83% and 79.17%, respectively (χ2= 9.56, P =0.03). The hypoalbuminemia severity positively correlated with vancomycin concentration in non-CRRT group. Conclusions Vancomycin concentration is generally higher in these critically ill elderly patients , in which hypoal-buminemia can prolong half-life of vancomycin. CRRT can effectively eliminate vancomycin , thus the TDM of van-comycin is very important to establish an effective and safe treatment protocol.
Keywords：Critically ill elderly patientsVancomycinTherapeutic drug monitoringContinuous renal replacement therapyHalf-life
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3857-3860 )