Clinical study of noninvasive positive pressure ventilation in treatment of chronic obstructive pulmonary disease with acute exacerbation of respiratory failure
LU Xi-liang
HUANG Xiang-zeng
Abstract：Objective To investigate the effect of noninvasive positive pressure ventilation NIPPV in treatment of chronic obstructive pulmonary disease with acute exacerbation of respiratory failure. Methods From April 2014 to January 2015, 80 patients with chronic obstructive pulmonary disease and acute exacerbation of respiratory failure in our hospital were enrolled in this study. The patients received anti-infectious, antispasmodic, expectorant, correct electrolyte imbalance and symptomatic and supportive cure. BiPAP Symchrony ventilator was applied in the patients in the treatment group, and low flow nasal catheter ventilation therapy was given to patients in the control group. The following parameters were observed and compared: (1)The clinical efficacy of two groups of patients; (2) RR, PaO2, PaCO2, pH changes of patients before and at 2, 24 hours after ventilation therapy. (3) Intubation and mechanical ventilation, mortality, average length of stay and complications that occur during treatment. Results After treatment, the total effective rate of patients in the treatment group was significantly higher than that of patients in the control group (P < 0.05). At the end of treatment, RR, PaO2, PaCO2, pH changes, aeration at 2 h, 24 h post ventilation of patients in the treatment group improved significantly (P<0.05). The intubation and mechanical ventilation rate, mean hospital stay of patients in the treatment group were significantly shorter than theose of patients in the control group (P<0.05). Conclusion To patients with chronic obstructive pulmonary disease and acute exacerbation of respiratory failure, NIPPV can improve clinical outcomes, improve the patient′s oxygen partial pressure and oxygen saturation, shorter hospital stays, inhibit the rates of mechanical ventilation.
Keywords：Chronic obstructive pulmonary diseaseAcute exacerbationRespiratory failureNoninvasive positive pressure ventilation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2842-2843,2844 )