Effects of Kunmu decoction on proliferation and apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis
CHEN Xiu-min
LIN Chang-song
LIU Qing-ping
XU Qiang
GUAN Tong
CHEN Ji-fan
LIU Feng-zhen
WU Ying
Abstract：Objective To investigate the effects of alcohol extract of Kunmu decoction on proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Methods Synovial tissues were obtained from patients with active RA received joint replacement or arthroscopy. The surface antigen and the amount of apoptotic cells were determined by flow cytometry. The inhibitive effect was detected by MTT assay. Results The CD90+surface antigen of synoviocytes was (94.78 ± 0.98)%. The inhibitive effect on the proliferation in all treatment groups were in a time-and dose-dependent manner. The apoptosis rate was increased in a dose-dependent manner among all dosage alcohol extract groups. Conclusion Kunmu decoction might inhibit proliferation and induce apoptosis of RA-FLS.
Keywords：ArthritisrheumatoidKunmu decoctionFibroblast-like synoviocytesProliferationApoptosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2793-2795,2796 )